A character has poor memory
Things can’t get worse, but they can.
A character’s child is cruel and heartless and grows up to be selfish and hurtful.
A character is unable to relieve another’s sorrow.
A character is oblivious to another person’s pain until it’s too late to help.
A character realizes he has forgotten obligations.
The friend of a character dies, but the character doesn’t know for a long time.
A character is planning to marry someone, but realizes she really doesn’t like him.
A character is planning to marry someone, but realizes her fiancé doesn’t like her.
A character is not recognized for the good she does.
A character is put on a pedestal for the good she does.
A character wants intimacy but doesn’t like to be around people for long.
A character likes being around people, but doesn’t want intimacy.
Being a widow.
Having one’s admiration count for something.
Having one’s opinion affect another’s action to a greater degree than wished.
Not being understood. Speaking an unknown language. Having the wrong set of social cues.
Friends committing suicide.
Worrying about money and feeling guilty about worrying.
Losing friends because you said something about them to someone else.
Being a boring person and knowing it.